What is Mesothelioma¿

Mesothelioma is a cancer of the smooth lining of the chest, lungs, heart, and abdomen. This skin layer is made up of mesothelial cells, hence the name mesothelioma. Mesothelioma is a diffuse but solid tumor that begins as a result of insult to the tissues caused by asbestos particles. These have penetrated into the pleural cavity of the chest or into the abdomen. Mesothelioma is either called pleural mesothelioma or peritoneal mesothelioma based on where it appears.

Because it occurs in such a small number of patients mesothelioma is often referred to as an orphan disease. Numbers of newly affected individuals in the United States have been reported to be between 2,500 and 3,000 every year. A steady rise in cases is reported in North America, Europe, Australia, and Asia.

In its early stages mesothelioma is difficult to detect as it may start with a thickening of the pleural rind, or fluid which can be associated with many other conditions. This rind is normally thin and smooth in the non diseased state. In time it begins to demonstrate progression forming a more pronounced irregular rind and nodules which coalesce into a crust that compresses and invades into adjacent structures compromising lung and cardiac function. In the abdominal cavity it can invade into the liver and bowel rendering the patient inoperable. Peritoneal mesothelioma it is often found coating the omentum described sometimes as a salt like sand like particles too numerous to count and impossible to remove without sacrificing the entire omentum. Involvement of the ovaries and fallopian tubes is not uncommon in women and often mesothelioma is confused with ovarian cancer. Once vital organs are involved or disease identified outside of the operative field surgery is no longer an option and patients are referred to chemotherapy or clinical trials.

For the vast majority of patients, as the tumor mass grows, once subtle symptoms will give way to weight loss, cough, respiratory infections, fatigue, shortness of breath, digestive and bowel problems and pain in the chest or abdomen, depending upon whether it is pleural or peritoneal. It may begin to weep fluid into the intracavitary space. In the chest cavity this is called an effusion and it fills the space where the lobes of the lung reside, next to the lining of the chest cavity, and often spreads into the area surrounding the heart creating symptoms similar to those observed in congestive heart failure. In peritoneal patients it is called ascites and it fills the abdomen bathing the visceral organs with this malignant fluid.


The symptoms gradually become more noticeable prompting the patient to seek a medical consultation. By this time the progression of the disease may already be too advanced as the tumor may have spread to the lymph nodes and/or begun to metastasize to remote organs of the body like the brain, spleen, liver or kidneys. Metastatic mesothelioma is considered late stage and incurable, given the current state of treatments. It is widely reported that only 10-20% of patients with pleural mesothelioma are diagnosed early enough for surgical intervention, the rest are referred on to palliative care No such figures have been reported in peritoneal mesothelioma.

Posted by Unknown on 9:23 AM. Filed under Health, Medical, Mesothelioma . You can follow any responses to this entry through the RSS 2.0